沙冲 博士 讲师
教育背景
2009.09至2015.06,江南大学 生物工程学院,发酵工程,获博士学位;
2005.09至2009.06,江南大学 生物工程学院,生物工程,获学士学位。
工作经历
2015年9月-至今 江苏大学生物质能源研究院
2019年7月-至今 山东福田药业有限公司 博士后
研究领域
研究新型工业用酶的克隆与高效表达技术;
利用合成生物学技术实现高附加值产物的全细胞合成及转化;
研究蛋白质表达调控及其结构与功能的分子催化机制;
研究光/电驱动的生物合成及电子传递机制。
科研项目
壳寡糖酶法合成的技术开发,2021年12月-2024年11月,主持,在研;
江苏省碳达峰碳中和科技创新专项资金,2022年1月-2024年12月,项目骨干,在研;
江苏省自然科学基金青年基金项目,主持,已结题。
主要研究论文
1. Jamile Mohammadi Moradian, Fu-Qiao Yang, Nuo Xu, Jia-Yi Wang, Jing-Xian Wang, Chong Sha*, Amjad Ali, Yang-Chun Yong. Enhancement of bioelectricity and hydrogen production from xylose by a nanofiber polyaniline modified anode with yeast microbial fuel cell. Fuel,2022, 326, 125056.
2. Chong Sha, Qiang Wang, Hongcheng Wang, Yilan Duan, Chongmao Xu, Lian Wu, Kesen Ma, Weilan Shao*, and Yu Jiang*. Characterization of Thermotoga neapolitana Alcohol Dehydrogenases in the Ethanol Fermentation Pathway. Biology-Basel, 2022, 11, 1318.
3. Chong Sha, Beenish Sadaqat, HongchengWang, Xingxing Guo, Weilan Shao⁎. Efficient xylan-to-sugar biotransformation using an engineered xylanase in hyperthermic environment. International Journal of Biological Macromolecules, 2020,157, 17-23.
4. Beenish Sadaqat#, Chong Sha#, Parveen Fatemeh Rupani, Hongcheng Wang, Wanbing Zuo and Weilan Shao*. Man/Cel5B, a Bifunctional Enzyme Having the Highest Mannanase Activity in the Hyperthermic Environment. Frontiers in Bioengineering and Biotechnology, 2021, 9, 637649.
5. Qiang Wang#, Chong Sha#, Hongcheng Wang, Kesen Ma, Juergen Wiegle, Abd El‑Fatah Abomohra* & Weilan Shao*. A novel bifunctional aldehyde/alcohol dehydrogenase catalyzing reduction of acetyl-CoA to ethanol at temperatures up to 95 degrees C. Scientific Reports, 2021, 11, 1050.
6. 邵蔚蓝,郭星星,沙冲*。大肠杆菌热休克或冷休克启动子调控的基因表达载体,微生物学通报,2017,44(6):1464-1470.
7. Chong Sha, Xiao-Wei Yu, Yan Xu, et al. Enhancement of lipase r27RCL production in Pichia pastoris by regulating gene dosage and co-expression with chaperone Protein Disulfide Isomerase. Enzyme and Microbial Technology, 2013, 53: 438-443.
8. Chong Sha, Xiao-Wei Yu, Yan Xu, et al. Efficient secretion of lipase r27RCL in Pichia pastoris by enhancing the disulfide bond formation pathway in the Endoplasmic Reticulum. Journal of Industrial Microbiology and Biotechnology, 2013, 40: 1241-1249.
9. Chong Sha, Xiao-Wei Yu, Yan Xu, et al. Impact of gene dosage on the Production of lipase from Rhizopus chinensis CCTCC M201021 in Pichia pastoris. Applied Biochemistry and Biotechnology, 2013, 169: 1160-1172.
10. Xiao-Wei Yu, Chong Sha, Yong-Liang Guo, Rong Xiao, Yan Xu, High-level expression and characterization of a chimeric lipase from Rhizopus oryzae for biodiesel production. Biotechnology for Biofuels, 2013, 6: 29.
专利
1. 沙冲,王洪成,邵蔚蓝。一种极耐热甘露聚糖酶及其制备方法与应用。CN 110819610 A
2. 喻晓蔚,徐岩,沙冲。一种分泌脂肪酶的毕赤酵母共表达伴侣蛋白基因工程菌及其应用。ZL 201210232950.8
联系地址及方式
江苏省镇江市学府路301号,江苏大学生物质能源研究院,邮编212013.
电子邮箱:shachong@ujs.edu.cn