张祯，男，江苏大学教授，博士生导师。
基本情况：本科毕业于中国农业大学动物科技学院动物营养专业；硕士就读于中国农业大学动物医学院基础兽医系；博士毕业于中国科学院生态环境研究中心，师从江桂斌院士进行污染物快速分析方法构建及应用方面的研究。2010年加入江苏大学环境与安全工程学院，2015年破格博导，2019年破格教授。
已发表100余篇SCI论文，主持6项国家级、多项省部级与横向合作项目。曾获2023年中国测试协会科技进步一等奖（第一）、2022年江苏省科技进步三等奖（第三）、2020年环境保护科学技术二等奖等（第四）。为中国毒理学会分析毒理专业委员会委员、首届CAIA智能医学检验分会委员、中国畜牧兽医学会兽医食品卫生学分会理事、江苏省毒理学会环毒专委会副主任委员等。
一、 主要项目：
国家自然科学基金项目：22476072；22176075；21876067；21577051；21107036等。
二、应用研发（2025年）：
1、多通道毒品检测笔（已完成）：可在5分钟内检测30种毒品；
2、病原体现场高通量快速分析平台（正在研发，30通道）；
3、高性能仿色谱电子鼻（正在研发）。
二、专利申请（2025年）
已授权专利：
1、张祯,周嘉龙,熊定辉,曾昆,贾博元,王欣雨,陶宇,张鑫硕. 一种基于核酸适配体修饰的仿生纳米酶MOF-808-Apt 的制备方法及其检测对氧磷的方法. CN 117960248 B. 2024.
2、张祯,张虎,崔键,曾昆,李金凤,王津,蔡籽年,周嘉龙. 基于特异性HRCA等温扩增结核分枝杆菌的序列组及应用. CN 118441078 B. 2024.
3、张祯,戴嘉辉,崔键,曾昆,李金凤,王津,蔡籽年,周嘉龙.一种球形核酸底物增强的CRISPR-Cas12a 系统检测非洲猪瘟的方法. CN 118374641 B. 2024.
4、张祯,曾昆,顾鑫凯,黄睿,李雪松. 锰单原子纳米催化剂的制备方法. CN 118341984 B. 2024.
5、张祯,李明,曾昆. 一种笔筒式多通道检测试剂盒. CN 221976885 U. 2024
6、张祯,韦达理,朱暖飞,熊定辉,汪颖,李铭炜. 一种集成智能手机平台的双酚A的双信号免疫分析方法. CN 114910646 B. 2025
7、Primer set of mycobacterium tuberculosis based on specific hrca isothermal amplification and an application thereof. Zhen Zhang, Hu Zhang, Kun Zeng, Ming Li. US 12,410,486 B1. 2025.
实审专利：
1、张祯,戴嘉辉,蔡籽年, 曾昆. 一种基于可调节DNA催化回路构建的单碱基突变检测方法及其应用. CN118853832A
2、张祯,王欣雨,吴成豪,曾昆. 一种聚腺嘌呤覆盖的AuNPs粘性耀斑材料及其制备方法与应用. CN119492716A.
3、张祯,王津,张振,曾昆.一种DNA串联超结构的细胞膜锚定生物传感器组合及其应用. CN118583833A
4、张祯,王文君,李雪松,贾博元. 一种杂交链式反应扩增的球形核酸酶及其制备方法和应用. CN118480595A
5、张祯,张虎,曾昆,李明. 一种用于结核分枝杆菌与利福平耐药检测的引物组、试剂盒及应用. CN120683277A
6、张祯,曾昆,黄睿,李明.聚多巴胺修饰的钴单原子纳米酶探针的制备方法及其检测装置. CN119986015A
7、张祯,赵颖,吴成豪,曾昆,张虎.熵驱动等温扩增引物促进富G序列增强DNA编导的银纳米簇荧光检测艰难梭菌的方法. CN119351398A
三、代表性文章
1、Dali Wei, Yunxiang Fan, Bohan Wu, Yuxuan Shen, Chunmeng Deng, Qiu Shen, Kun Zeng, Ligang Hu, Jingfu Liu, Zhugen Yang, Zhen Zhang*. Enabling Emergency Response to Arsenic Contamination: Simultaneous and Rapid Identification of Arsenic Speciation by a Machine Learning-Driven Fluorescent Sensor Array. Environ. Sci. Technol. 2025, 59, 24526–24537.
2、Jialong Zhou, Dinghui Xiong, Hu Zhang, Jiaxuan Xiao, Rui Huang, Ze Qiao, Zhugen Yang*, Zhen Zhang*. Targeted Enrichment of Nucleic Acid Bionic Arms Enhances the Hydrolysis Activity of Nanozymes for Degradation and Real-Time Monitoring of Organophosphorus Pesticides in Water. Environ. Sci. Technol. 2025, 59, 1844-1853.
3、Nuanfei Zhu, Yixing Tian, Sinuo Tao, Ze Qiao, Zhugen Yang, Ligang Hu, Jingfu Liu, Zhen Zhang*. Chromium Speciation Monitoring Platform for Drinking Water: Machine Learning-Assisted Dual-Emission Fluorescence Sensor Array. Environ. Sci. Technol. Lett. 2025, 12, 792-798.
4、Jin Wang, Yunlong Qin, Raanan Carmieli, Vitaly Gutkin, Eli Pikarsky, Zhen Zhang* Xinghua Chen* and Itamar Willner*. Enzyme-Loaded Fe3+-doped ZIF-90 particles as catalytic bioreactor hybrids operating biocatalytic cascade. Chem. Sci. 2025, 16, 9705-9714.
5、Jin Wang, Zhugen Yang, Kun Wang, Zhen Zhang*. A Tandem Cubic DNA Nanostructures Cell Membrane Surface Sensing Platform for In Situ Monitoring of Multiple Cytotoxicity-Related Biomarkers. Anal. Chem. 2025, 97, 23496-23504.
6、Xuesong Li, Xiaohan Zhang, Jin Wang, Xiangyang Wu, Zhen Zhang*, Juewen Liu*. EDTA-Masked Tl+ Detection Using a Pair of Non-G-Quadruplex Aptamers with Opposite Fluorescence Responses. Anal. Chem. 2025, 97, 17242-17250.
7、Xuesong Li, Xiaohan Zhang, Jin Wang, Xiangyang Wu, Zhen Zhang*, Juewen Liu*. EDTA-Masked Tl+ Detection Using a Pair of Non-G-Quadruplex Aptamers with Opposite Fluorescence Responses. Anal. Chem. 2025, 97, 17242-17250.
8、Jiahui Dai, Beibei Wu, Fengxiang Ai, Zhugen Yang, Yanyan Lu, Cai Zinian, Kun Zeng, Zhen Zhang*, Exploiting the Potential of Spherical PAM Antenna for Enhanced CRISPR-Cas12a: A Paradigm Shift toward a Universal Amplification Free Nucleic Acid Test Platform. Anal. Chem. 2025, 97, 1236-1245.
9、Nuanfei Zhu, Xiangheng Niu, Zheng Liang, Yixing Tian, Hongyi Yin, Ze Qiao, Zhen Zhang*. Cell-Inspired Microreactor with Compartmentalized Active Sites for Development of Cascade Catalysis System in Biosensing. Anal. Chem. 2024, 96, 18736-18744.
10、Dali Wei, Hu Zhang, Yu Tao, Kaixuan Wang, Ying Wang, Chunmeng Deng, Rongfei Xu, Nuanfei Zhu, Yanyan Lu, Kun Zeng, Zhugen Yang, Zhen Zhang*. Dual-Emission Single Sensing Element-Assembled Fluorescent Sensor Arrays for the Rapid Discrimination of Multiple Surfactants in Environments. Anal. Chem. 2024, 96, 4987-4996.
11、Jiaxuan Xiao, Xiaofeng Yang, Xinshuo Zhang, Xiangheng Niu, Yujia Guo, Nuanfei Zhu, Kun Zeng, Zhen Zhang*. Investigation for Regulation of a DNA-Programmed Bimetallic Nanozyme and Its Biosensing Applications. Anal. Chem. 2024, 96, 49, 19796-19802.
12、Jin Wang, Kaixuan Wang, Hanyong Peng, Zhen Zhang*, Zhugen Yang, Maoyong Song, Guibin Jiang. Entropy-Driven Three-Dimensional DNA Nanofireworks for Simultaneous Real-Time Imaging of Telomerase and MicroRNA in Living Cells. Anal. Chem. 2023, 95, 4138-4146.
13、Dinghui Xiong, Jie Cheng, Fengxiang Ai, Xinyu Wang, Jiaxuan Xiao, Fang Zhu, Kun Zeng, Kun Wang, Zhen Zhang*. Insight into the Sensing Behavior of DNA Probes Based on MOF-Nucleic Acid Interaction for Bioanalysis. Anal. Chem. 2023, 95, 5470-5478.
14、Dali Wei, Mingwei Li, Fengxiang Ai, Kun Wang, Nuanfei Zhu, Ying Wang, Daqiang Yin*, Zhen Zhang*. Fabrication of Biomimetic Cascade Nanoreactor Based on Covalent Organic Framework Capsule for Biosensing. Anal. Chem. 2023, 95, 11052-11060.
15、Nuanfei Zhu, Chengbin Liu, Rui Liu, Xiangheng Niu, Dinghui Xiong, Kun Wang, Daqiang Yin, and Zhen Zhang*. Biomimic Nanozymes with Tunable Peroxidase-like Activity Based on the Confinement Effect of Metal-Organic Frameworks (MOFs) for Biosensing. Anal. Chem. 2022, 94, 4821-4830.
16、Dali Wei, Dinghui Xiong, Nuanfei Zhu, Ying Wang, Xialin Hu, Biying Zhao, Jinhui Zhou, Daqiang Yin*, and Zhen Zhang*. Copper Peroxide Nanodots Encapsulated in a Metal-Organic Framework for Self-Supplying Hydrogen Peroxide and Signal Amplification of the Dual-Mode Immunoassay. Anal. Chem. 2022, 94, 12981-12989.
17、Jian Lu, Jin Wang, Xialin Hu, Eric Gyimah, Salome Yakubu, Kun Wang, Xiangyang Wu, and Zhen Zhang*, Electrochemical biosensor based on tetrahedral DNA nanostructures and G‑quadruplex-hemin conformation for the ultrasensitive detection of microRNA-21 in serum. Anal. Chem. 2019, 91, 7353-7359.
18、Dali Wei, Mengfan Li, Yudi Yang, Chunmeng Deng, Fang Zhu, Ming Li, Yibin Deng*, Zhen Zhang*. Ligand Microenvironment-Regulated Nanozymes Enabled Machine Learning-Assisted Sensor Array for Simultaneous Identification of Phenolic Pollutants. ACS Sens. 2025, 10, 5245-5255.
19、Xuesong Li, Jie Cheng, Kun Zeng, Shulin Wei, Jiaxuan Xiao, Yanyan Lu, Fang Zhu, Zhanhui Wang, Kun Wang, Xiangyang Wu, Zhen Zhang*. Accelerated Hybridization Chain Reaction Kinetics Using Poly DNA Tetrahedrons and Its Application in Detection of Aflatoxin B1. ACS Appl. Mater. Interfaces. 2023, 15, 41237-41246.
20、Dali Wei, Ying Wang, Nuanfei Zhu, Jiaxuan Xiao, Xuesong Li, Ting Xu, Xialin Hu, Zhen Zhang*, and Daqiang Yin* A Lab-in-a-Syringe Device Integrated with a Smartphone Platform: Colorimetric and Fluorescent Dual-Mode Signals for On-Site Detection of Organophosphorus Pesticides. ACS Appl. Mater. Interfaces. 2021, 13, 48643-48652.
21、Fang Zhu, Hu Zhang, Ruoxi Wu, Yanyan Lu, Jin Wang, Ravikumar A, Tamil Selvan G, Nuanfei Zhu, Zhen Zhang*, Jun Tang*. A dual-signal aptasensor based on cascade amplification for ultrasensitive detection of aflatoxin B1. Biosens. Bioelectron. 2024, 250, 116057.
22、Jiaxuan Xiao, Kun Wang, Yanmin Zou, Eric Gyimah, Salome Yakubu, Zhen Zhang*. A novel signal amplification strategy based on the competitive reaction between 2D Cu-TCPP(Fe) and polyethyleneimine (PEI) in the application of an enzyme-free and ultrasensitive electrochemical immunosensor for sulfonamide detection, Biosens. Bioelectron. 2019, 150, 11883.
23、Mingyue Yang, Xiangyang Wu, Xialin Hu, Kun Wang, Can Zhang, Eric Gyimah, Salome Yakubu, Zhen Zhang*. Electrochemical immunosensor based on Ag+-dependent CTAB-AuNPs for T ultrasensitive detection of sulfamethazine. Biosens. Bioelectron. 2019, 144, 111643.
24、Jin Wang, Jian Lu, Shuaibing Dong, Nuanfei Zhu, Eric Gyimah, Kun Wang, Yong Li, Zhen Zhang*.An ultrasensitive electrochemical biosensor for detection of microRNA-21 based on redox reaction of ascorbic acid/iodine and duplex-specific nuclease assisted target recycling. Biosens. Bioelectron. 2019, 130, 81-87.
